June 2018: Undergraduate Durell Bico joins the lab.
June 2018: A manuscript describing our first explorations of the use of bifunctional catalysts with Group 10 metals has been submitted (Eric Greve first author), and is available on ChemRxiv: https://doi.org/10.26434/chemrxiv.6394478.v1
It features an innovative bifunctional catalyst designed, modeled, and synthesized by Eric.
June 2018: Our first examples of potentially anti-metastatic bivalent GPCR ligands have been submitted for patent. A manuscript from Mark Majewski and Disha Gandhi has also been submitted and is available at ChemRxiv: https://doi.org/10.26434/chemrxiv.6394430.v1
May 2018: Yibiao Wu’s seminal work on the synthesis of a new sordarin-inspired antifungal scaffold has been submitted for patent. A manuscript has also been submitted and is available at ChemRxiv: https://doi.org/10.26434/chemrxiv.6394409.v1
May 2018: Lab alumnus Anson Bautista completed his degree in Biomedical Sciences and is headed to Columbia U to begin medical school. Congratulations Anson!
May 2018: Lab alumnus Ryan Engel completed his degree in Biomedical Sciences and is headed to the University of Pennsylvania to begin dental school. Congratulations Ryan!
May 2018: Eric Greve wins the department Bournique Award for top qualifying Ph.D. student.
May 2018: Chris wins the department Senior Award for teaching and mentorship.
May 2018: Vlada Kot wins the department award for top student in Honors General Chemistry.
May 2018: Chris presents a poster at the ACS National Medicinal Chemistry Symposium in Nashville, TN: Novel approaches to the modulation of Protease-Activated Receptors (PARs): Assay development and medicinal chemistry.
April 2018: Jacob Porter’s work on the design and investigation of putative Cu(I) catalyst systems for the direct addition of aldehydes/ketones to alkynes has been submitted, and is available on ChemRxiv:
It is notable for documenting our first computational-powered (density functional theory) attempts at de novo catalyst design, a strategy that we believe is very promising for bifunctional catalysis. Eric Greve also made important contributions to these efforts.
April 2018: Disha and Mark’s work on the development of a new protocol for measuring PAR-triggered calcium mobilization in endothelial cells is published in Bioorganic and Medicinal Chemistry. This paper is also important because it demonstrates how our parmodulin compounds are reversible, allosteric inhibitors of PAR1 (unlike the clinical drug vorapaxar). It also features the preparation of a modified PAR1 ligand suitable for the preparation of conjugate compounds.
An earlier version of the manuscript is also available at ChemRxiv:
April 2018: Chris and Disha’s manuscript on analogs of the snail toxin BrMT as K+ channel modulators is accepted in Biochemistry. This collaborative project (with the Sack electrophysiology lab at UC Davis and the Andersen electrophysiology/channel lab at Weill Cornell Medical College) describes stabilized analogs of the disulfide natural product, and notably helps differentiate target-specific effects of channel modulators from non-specific membrane perturbation:
An earlier version of the manuscript is also available at ChemRxiv:
March 2018: Trevor Foster is nominated by the College for the 2018 Outstanding Senior Award. Trevor finished his degree early, and is already working as a patent law clerk prior to starting law school at USC in Fall 2018. Congratulations Trevor!
February 2018: Eric Greve wins the prestigious Schmitt Fellowship.
January 2018: Undergraduate Vlada Kot joins the lab.
November 2017: Ricardo Rosas passes his Ph.D. qualifying.
November 2017: Roland Diby presents a poster on his parmodulin-related work at the Marquette Honors Student poster session.
October 2017: Eric Greve passes his Ph.D. qualifying.
October 2017: Graduate student Jacob DeRousse joins the lab.
August 2017: Disha Gandhi presents a poster at the National ACS meeting in Washington, DC: Strategies for the modulation of protease-activated receptors (PARs).
July 2017: Jacob Porter is invited to attend the ACS Organic Chemistry Graduate Research Symposium in Portland, OR, where he presents a poster on his catalysis research: Hybrid Lewis Acid/Lewis Base Catalysis for Carbon-Carbon Bond Formation.
June 2017: Undergraduate Abdulmohsen Alsafran joins the lab.
May 2017: Undergraduate Roland Diby (Milwaukee Area Technical College) joins the lab.
April 2017: Disha Gandhi (parmodulin project) and Jacob Porter (bifunctional catalyst project) present posters at the Yao Yuan Biotech-Pharma symposium at University of Chicago.
April 2017: Lab undergrad. alumnus Ben Pleuhs wins the department inorganic chemistry undergrad. student of the year award.
April 2017: Jacob Anderson, Anson Bautista, Ben Lamb, and Mallory Mews present posters on the Pyruvate Carboxylase project at the Marquette Biological Sciences undergraduate poster session.
April 2017: Trevor Foster wins a summer fellowship from Marquette University in support of his work on the parmodulin and bivalent ligand projects.
January 2017: Undergraduates Ryan Engel and Kricket Luckow join the lab.
October 2016: Chris presents a poster on the parmodulin project at the 17th Annual Great Lakes GPCR Retreat in Chicago: Parmodulins as biased ligands of Protease-Activated Receptor 1 (PAR1).
October 2016: Disha Gandhi (parmodulin project) and Eric Greve (bifunctional catalysis project) present posters at the Chicago Organic Symposium hosted by Loyola University.
October 2016: Trevor Foster presents a poster at the Marquette Honors student symposium on the parmodulin project.
September 2016: Our participation in the new Marquette Experience in Drug Discovery and Development (ME(D)3) is kicked off by the start of medicinal chemistry research by undergraduates Jacob Anderson, Anson Bautista, Ben Lamb, Mallory Mews, who will be working with Ricardo Rosas and colleagues in the St. Maurice lab on the structure-based design of Pyruvate Carboxylase inhibitors.
August 2016: Chris presents a talk on the bifunctional catalysis project at the National ACS meeting in Philadelphia: Hybrid catalysts for carbon–carbon bond formation.
May 2016: Kaitlin Kentala graduates a year early with her B.S. in Biochemistry. Kaitlin is reluctantly departing Marquette and the Dockendorff Lab to start her graduate studies in Chemistry at the University of Chicago. Congratulations Kaitlin!
May 2016: Our full paper describing our collection of first-generation hybrid catalysts (Dennis Wiedenhoeft first author) is published in Tetrahedron: http://dx.doi.org/10.1016/j.tet.2016.05.014
April 2016: Kaitlin Kentala wins the Way Klingler College of Arts & Sciences Outstanding Undergraduate Scholar Award.
April 2016: Our first manuscript on hybrid catalysis (Dennis Wiedenhoeft first author) is published in Synthesis: http://dx.doi.org/10.1055/s-0035-1560436
April 2016: Disha Gandhi presents a poster on the parmodulin project at the Yao Yuan Biotech-Pharma symposium at University of Chicago-Illinois.
March 2016: Jacob Porter is nominated for the prestigious Eisch Fellowship.
March 2016: Our new Shimadzu prep. HPLC system has been installed and is firing on all cylinders. Thank you to Dennis and Disha for working to get everything operating smoothly.
January 2016: Mark Majewski joins the lab as a postdoctoral fellow after completing his dissertation with Prof. Marvin Miller (Notre Dame).
December 2015: Trevor Foster joins the lab as an undergraduate researcher.
November 2015: Ben Pleuhs and Kaitlin Kentala present posters on the parmodulin project at an undergraduate research poster session at Marquette.
October 2015: Jacob Porter passes his Ph.D. candidacy.
Fall 2015: Ricardo Rosas and Eric Greve join the lab as graduate students.
August 2015: NIH National Heart, Lung, and Blood Institute announces support of our studies on the modulation of protease-activated receptors (PARs): https://projectreporter.nih.gov/project_info_description.cfm?aid=8879915&icde=26981779&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC
July 2015: Raj Virdi presents a poster on the aldol catalyst project at the McNair Scholars poster session at Marquette.
July 2015: ACS Petroleum Fund announces support of our hybrid catalysis project for carbon–carbon bond formation:
June 2015: Chris presents a poster and talk on the parmodulin project at the FASEB Proteases in Hemostasis and Vascular Biology conference in Keystone, CO: Biased antagonists of PAR1.
May 2015: Disha Gandhi is awarded the R. A. Bournique Memorial and Denis J. O’Brien Summer Fellowship.
May 2015: Kaitlin Kentala is awarded a summer research grant by the Klingler College of Arts and Sciences for the proposal entitled, “Novel Modulators of Protease-Activated Receptor 1 (PAR1)”.
May 2015: Disha Gandhi and Jacob Porter are nominated for the R. Haymaker Award for top teaching assistant.
April 2015: NIH NCATS and the Clinical & Translational Institute of Southeast Wisconsin announce support of our new heterobivalent ligand project (in collaboration with Dr. Hartmut Weiler’s lab), with the goal of developing a new treatment for sepsis:
April 2015: Disha Gandhi presents a poster on the parmodulin project at the H. C. Brown lectures at Purdue University.
Spring 2015: Our proposal (Prof. Martin St. Maurice PI) for the Marquette Experience in Drug Discovery and Development (ME(D)3) is funded by the Marquette Innovation Fund. We will be spearheading the design and synthesis of novel Pyruvate Carboxylase (PC) inhibitors: http://www.marquette.edu/biology/undergrad-med3.shtml
March 2015: Disha Gandhi is nominated for the prestigious Eisch Fellowship.
Winter 2015: Adam Benoit (postdoc) departs to start a new position as a flow chemistry specialist with Sigma-Aldrich. Congratulations Adam!