Publications

Peer-Reviewed Publications

(* indicates corresponding author)

32. Multifunctional Heterocyclic Scaffolds for Hybrid Lewis acid/Lewis base Catalysis of Carbon–Carbon Bond Formation. 

Wiedenhoeft, D.; Benoit, A. R.; Wu, Y.; Porter, J. D.; Meyle, E.; Yeung, T. H. W.; Huff, R.; Lindeman, S. V.; Dockendorff, C.*

Tetrahedron 2016, 72, 3905–3916. http://dx.doi.org/10.1016/j.tet.2016.05.014

2016 05 20 Tetrahedron graphical abstract_med

 


31. Design and synthesis of oxazoline-based scaffolds for hybrid Lewis acid/Lewis base catalysis of carbon–carbon bond formation. 

Wiedenhoeft, D.; Benoit, A. R.; Porter, J. D.; Wu, Y.; Virdi, R. S.; Shanaa, A.; Dockendorff, C.*

Synthesis 2016, 48, 2413–2422. http://dx.doi.org/10.1055/s-0035-1560436

2016 02 15 Synthesis graphical abstract medres


30. Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Dockendorff, C.*; Faloon, P. W.; Pu, J.; Yu, M.; Johnston, S.; Bennion, M.; Dandapani, S.; Perez, J. R.; Munoz, B.; Palmer, M. A.; Schreiber, S. L.; Krieger, M.*

Biorg. Med. Chem. Lett. 2015, 25, 2100–2105. http://dx.doi.org/10.1016/j.bmcl.2015.03.073

2015 ML312_BMCL


29. Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Dockendorff, C.*; Faloon, P. W.; Germain, A.; Yu, M.; Youngsaye, W.; Nag, P. P.; Bennion, M.; Penman, M.; Nieland, T. J. F.; Dandapani, S.; Perez, J. R.; Munoz, B.; Palmer, M.; Schreiber, S. L.; Krieger, M.*

Biorg. Med. Chem. Lett. 2015, 25, 2594-2598http://dx.doi.org/10.1016/j.bmcl.2015.03.074

2015 ML279 BMCL_TOC graphic 2


28. Indoline-thiazole based inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Dockendorff, C.*; Faloon, P. W.; Yu, M.; Youngsaye, W.; Penman, M.; Nieland, T. J. F.; Nag, P. P.; Lewis, T. A.; Pu, J.; Bennion, M.; Negri, J.; Paterson, C.; Lam, G.; Dandapani, S.; Perez, J. R.; Munoz, B.; Palmer, M. A; Schreiber, S. L.; Krieger, M.*

ACS Med. Chem. Lett. 2015, 6, 375–380. http://dx.doi.org/10.1021/ml500154q

2015 ML278_ACS MCL


27. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.

Aisiku, O.; Peters, C. G.; De Cuenynck, K.; Ghosh, C. C.; Dilks, J. R.; Fustolo-Gunnink, S. F.; Huang, M.; Dockendorff, C.; Parikh, S. M.; Flaumenhaft, R.*

Blood 2015 125, 1976–1985. http://dx.doi.org/10.1182/blood-2014-09-599910

Featured editorial in Blood: http://dx.doi.org/10.1182/blood-2015-01-623835


26. Identification of ML359 as a small molecule inhibitor of protein disulfide isomerase. VerPlank, L.*; Khodier, C.; Nag, P. P.*; Pu, J.; Wurst, J.; Pilyugina, T.; Dockendorff, C.; Galinski, C. N.; Scalise, A. A.; Passam, F.; van Hessem, L.; Dilks, J.; Kennedy, D. R.; Flaumenhaft, R.*; Palmer, M. A. J.; Dandapani, S.; Munoz, B.; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2013http://www.ncbi.nlm.nih.gov/books/NBK189925/


 25. Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

Dockendorff, C.*; Nagiec, M. M.*; Weїwer, M.; Buhrlage, S.; Ting, A.; Nag, P. P.; Germain, A.; Kim, H.-J.; Youngsaye, W.; Scherer, C.; Bennion, M.; Xue, L.; Stanton, B. Z.; Lewis, T. A.; MacPherson, L.; Palmer, M.; Foley, M. A.; Perez, J. R.; Schreiber, S. L.

ACS Med. Chem. Lett. 20123, 808–813. (link)

2012 Hedgehog pathway inhibitors_ACS MCL


24. A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake – Probe 3. Faloon, P. W.*; Dockendorff, C.*; Yu, M.; Bennion, M.; Johnston, S.; Negri, J; Dandapani, S.; Munoz, B.; Perez, J. R.; Palmer, M.; Penman, M.; Nieland, T. J. F.; Krieger, M.*; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2012. http://www.ncbi.nlm.nih.gov/books/NBK143554/


23. Overcoming Fluconazole Resistance in Candida albicans Clinical Isolates with Tetracyclic Heterocycles. Youngsaye, W.; Dockendorff, C.; Vincent, B.; Hartland, C. L.; Bittker, J. A.;  Dandapani, S.; Palmer, M.; Whitesell, L.; Lindquist, S.; Schreiber, S. L.; Munoz, B.* Bioorg. Med. Chem. Lett. 2012, 22, 3362–3365. http://dx.doi.org/10.1016/j.bmcl.2012.02.035


22. Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.

Dockendorff, C.*; Aisiku, O.; VerPlank, L.; Dilks, J. R.; Smith, D. A.; Gunnink, S. F.; Dowal, L.; Negri, J.; Palmer, M.; MacPherson, L.; Schreiber, S. L.; Flaumenhaft, R.*

ACS Med. Chem. Lett. 20123, 232–237. (link)

2012 ML161_ACS MCL


21. A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake – Probe 2. Faloon, P. W.*; Dockendorff, C.*; Germain, A.; Yu, M.; Nag, P. P.; Youngsaye, W.; Bennion, M.; Lam, G.; Paterson, C.; Dandapani, S.; Munoz, B.; Perez, J. R.; Palmer, M.; Nieland, T. J. F.; Krieger, M.*; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2011. http://www.ncbi.nlm.nih.gov/books/NBK133438/


20. A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake – Probe 1. Faloon, P. W.*; Dockendorff, C.*; Youngsaye, W.; Yu, M.; Nag, P. P.; Lewis, T. A.; Bennion, M.; Paterson, C.; Lam, G.; Dandapani, S.; Munoz, B.; Perez, J.; Palmer, M.; Nieland, T. J. F.; Krieger, M.*; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2011. http://www.ncbi.nlm.nih.gov/books/NBK133420/


19. Identification of Small-Molecule Inhibitors of Trypansoma Cruzi Replication. Germain, A. R. Carmody, L. C.; Dockendorff, C.; Galan-Rodriguez, C.; Rodriguez, A.; Johnston, S.; Bittker, J. A.; MacPherson, L.; Dandapani, S.; Palmer, M.; Schreiber, S. L.; Munoz, B.* Biorg. Med. Chem. Lett. 2011, 21, 7197–7200. http://dx.doi.org/10.1016/j.bmcl.2011.09.057


18. Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence – Probe 3. Hartland, C. L.*; Youngsaye, W.*; Dockendorff, C.; Johnston, S.; Bittker, J.; Vincent, B.; Whitesell, L.; Dandapani, S.; MacPherson, L.; Munoz, B.; Palmer, M.; Lindquist, S.*; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2011http://www.ncbi.nlm.nih.gov/books/NBK98918/


17. Chemical Genetic Analysis of Platelet Granule Secretion–Probe 3. VerPlank, L.*; Dockendorff, C.*; Negri, J.; Perez, J. R.; Dilks, J. R.; MacPherson, L.; Palmer, M.; Flaumenhaft, R.*; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2010. http://www.ncbi.nlm.nih.gov/books/NBK55066/


16. Chemical Genetic Analysis of Platelet Granule Secretion–Probe 2. VerPlank, L.*; Dockendorff, C.*; Negri, J.; Perez, J. R.; Dilks, J. R.; MacPherson, L.; Palmer, M.; Flaumenhaft, R.*; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2010. http://www.ncbi.nlm.nih.gov/books/NBK55073/


15. Chemical Genetic Analysis of Platelet Granule Secretion–Probe 3. VerPlank, L.; Dockendorff, C.; Negri, J.; Perez, J. R.; Dilks, J. R.; MacPherson, L.; Palmer, M.; Flaumenhaft, R.; Schreiber, S. L. Probe Reports from the NIH Molecular Libraries Program 2010. https://mli.nih.gov/mli/?dl_id=1254


14. Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions. Sunderhaus, J. D.; Dockendorff, C.; Martin, S. F.* Tetrahedron 2009, 65, 6454–6469. http://dx.doi.org/10.1016/j.tet.2009.05.009


13. Discovery of μ-Opioid Selective Ligands Derived from 1-Aminotetralin Scaffolds Made via Metal-Catalyzed Ring-Opening Reactions. Dockendorff, C.*; Jin, S.; Olsen, M.; Lautens, M.; Coupal, M.; Hodzic, L. Payza, K.; Walpole, C.; Tomaszewski, M.* J. Bioorg. Med. Chem. Lett. 2009, 19, 1228–1232. http://dx.doi.org/10.1016/j.bmcl.2008.12.095 Featured in Synfacts, Sept. 2009 issue.


12. Concise Enantioselective Total Syntheses of (+)-Homochelidonine, (+)-Chelamidine, (+)-Chelidonine, (+)-Chelamine and (+)-Norchelidonine via a Pd(II)-catalyzed Ring-Opening Strategy. Fleming, M. J.; McManus, H. A.; Rudolph, A.; Chan, W. H.; Ruiz, J.; Dockendorff, C.; Lautens, M.* Chem. Eur. J. 2008, 14, 2112–2124. http://dx.doi.org/10.1002/chem.200701775


11. Applications of Multicomponent Reactions for the Synthesis of Diverse Heterocyclic Scaffolds. Sunderhaus, J. D.; Dockendorff, C.; Martin, S. F.* Org. Lett. 2007, 9, 4223–4226. http://dx.doi.org/10.1021/ol7018357


10. Rhodium-Catalyzed Asymmetric Allylic Substitution with Boronic Acid Nucleophiles. Ménard, F.; Chapman, T. M.; Dockendorff, C.; Lautens, M.* Org. Lett. 2006, 8, 4569–4572. http://dx.doi.org/10.1021/ol061777l Featured in Synfacts, Dec. 2006 issue.


9. tert-Butyl (2-phenyl-1,2-dihydro-1-naphthyl)-carbamate. Dockendorff, C.; Lautens, M.; Lough, A. J.* Acta Cryst. 2006E62, o107. http://dx.doi.org/10.1107/S1600536805039747


8. 2-Methoxy-N-[2-(3-thienyl)-1,2,3,4-tetrahydro-1-naphthyl]acetamide. Dockendorff, C. Lautens, M.; Lough, A. J.* Acta Cryst. 2006, E62, o639. http://dx.doi.org/10.1107/S1600536806001036


7. 2-(1-Phenylsulfonyl-1H-indol-3-yl)-1,2-dihydronaphthalen-1-ol. Dockendorff, C.; Lautens, M.; Lough, A. J.* Acta Cryst. 2006, E62, o1030. http://dx.doi.org/10.1107/S1600536806004776


6. 2,4-Dimethyl-6-phenyl-8-oxabicyclo[3.2.1]-octan-3-one. Dockendorff, C.; Lautens, M.; Lough, A. J.* Acta Cryst. 2006, E62, o1601. http://dx.doi.org/10.1107/S1600536806009779


5. Aryne Diels-Alder Reactions with Acyclic Dienes: Scope and Diastereoselectivity. Dockendorff, C.; Sahli, S.; Olsen, M.; Milhau, L.; Lautens, M.* J. Am. Chem. Soc. 2005, 127, 15028–15029. http://dx.doi.org/10.1021/ja055498p


4. Palladium(II) Catalyst Systems for the Addition of Boronic Acids to Bicyclic Alkenes: New Scope and Reactivity. Lautens, M.*; Dockendorff, C. Org. Lett. 2003, 5, 3695–3698. http://dx.doi.org/10.1021/ol035369i


3. Rhodium-Catalyzed Asymmetric Ring Opening of Oxabicyclic Alkenes with Organoboronic Acids. Lautens, M.*; Dockendorff, C.; Fagnou, K.; Malicki, A. Org. Lett. 2002, 4, 1311–1314. http://dx.doi.org/10.1021/ol0256062


2. A Mild Procedure for the Reduction of Pyridine N-Oxides to Piperidines Using Ammonium Formate. Zacharie, B.*; Moreau, N.; Dockendorff, C. J. Org. Chem. 2001, 66, 5264–5265. http://dx.doi.org/10.1021/jo015649g


1. Synthesis of Protected L-4-[Sulfono(difluoromethyl)]phenylalanine and Its Incorporation into a Peptide. Liu, S.; Dockendorff, C.; Taylor, S. D.* Org. Lett. 2001, 3, 1571–1574. http://dx.doi.org/10.1021/ol0158664

Patent Applications

7. Heterocycle-bisamide inhibitors of scavenger receptor bi. Dandapani, S.; Dockendorff, C.; Falloon, P.; Germain, A.; Krieger, M.; Munoz, B.; Nag, P. P.; Nieland, T.; Youngsaye, W.; Yu, M. WO 2014/063168 Filed 10/21/2013.

6. Thiazole-based inhibitors of scavenger receptor bi. Dandapani, S.; Dockendorff, C.; Falloon, P.; Krieger, M.; Lewis, T. A.; Munoz, B.; Nag, P. P.; Nieland, T.; Youngsaye, W.; Yu, M. WO 2014/063167 Filed 10/21/2013.

5. Sonic Hedgehog Modulators. Buhrlage, S.; Dockendorff, C.; Foley, M.; Kim, H.-J.; Germain, A.; MacPherson, L.; Nag, P.; Schreiber, S.; Ting, A.; Weiwer, M.; Youngsaye, W. US 2014/0094462 Filed 2/28/2013.

4. Heterocycle-Bisamide Inhibitors of Scavenger Receptor BI. Dandapani, S.; Dockendorff, C.; Falloon, P.; Germain, A.; Krieger, M.; Munoz, B.; Nag, P. P.; Nieland, T.; Youngsaye, W.; Yu, M. WO 2014/063168 Filed 10/19/2012.

3. Thiazole-based Inhibitors of Scavenger Receptor BI. Dandapani, S.; Dockendorff, C.; Falloon, P.; Krieger, M.; Lewis, T. A.; Munoz, B.; Nag, P. P.; Nieland, T.; Youngsaye, W.; Yu, M. WO 2014/063167 Filed 10/19/2012.

2. Compounds and Methods for Treating Diseases Mediated by Protease Activated Receptors. Dockendorff, C.; Flaumenhaft, R.; MacPherson, L. WO 2012/040636; US 2013/0331411 Filed 9/23/2011.

1. Compounds and Methods for the Treatment of Cancer Stem Cells. Germain, A.; Munoz, B.; Lewis, T. A.; Ting, A.; Youngsaye, W.; Nag, P. P.; Dockendorff, C.; Fernandez, C. V.; Donckele, E.; Morgan, B.; Skoda, E.; Suh, B.-C. WO 2013/032907 Filed 8/26/2011.

Advertisements